GASTROENTEROLOGY ARTICLE OF THE WEEK

April 27, 2000

 Steindl PE, Ferenci P.  Clinical issues in the management of alcoholic liver disease.  Clinics in Liver Disease 1998;2:765-779.

 1.  Which of the following parameters suggest alcohol consumption

            a.  low uric acid

            b.  low magnesium

            c.  high triglycerides

            d.  polyclonal hypergammaglobulinemia

            e.  increases in serum IgA

 True or False 

2.  Over 90% of alcoholics with abnormal liver enzyme levels have alcoholic liver disease on liver biopsy.

3.  Increased iron stores in alcoholic patients with cirrhosis are usually due to co-existent genetic hemochromatosis

4.  Alcoholic steatosis is not associated with liver failure.

5.  Serum carbohydrate deficient transferrin is elevated in patients who consume alcohol.

6.  Alcohol use promotes acetaminophen-related toxicity by inducing the P450 system and depleting glutathione.

7.  Patients with alcoholic liver disease rarely develop chronic pancretitis.

8.  Factors that may explain the increased iron stores in alcoholics include

            a.  increased meat intake

            b.  increased iron absorption

            c.  impaired erythropoiesis

            d.  hemolysis

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