GASTROENTEROLOGY ARTICLE OF THE WEEK
August 24, 2006
Moo-In P, Camilleri M. Gastroparesis: clinical update. Am J Gastroenterol 2006;101-1129-39.
1. Typical features of diabetic gastroparesis include
a. increased frequency of antral contractions
b. antro-duodenal incoordination
c. antral hypomotility
d. abnormal post-prandrial gastric accommodation
2. The most common form of gastroparesis is:
a. diabetic gastroparesis
b. post-surgical gastroparesis
c. post-infectious grastroparesis
d. idiopathic gastroparesis
e. drug-induced gastroparesis
3. Metoclopramide
a. acts in the stomach and entire small bowel to improve motility
b. the prokinetic effects on gastric emptying are sustained with chronic use
c. it has prokinetic and anti-emetic properties
d. using the liquid formula may improve clinical efficacy
e. Is a 5HT3 agonist and a D2 antagonist
True or False
4. A cow in the park is the first author of this article
5. Fullness, bloating and nausea are typical symptoms of gastroparesis and are not usually seen with accelerated gastric emptying
6. Gastric emptying of liquids may remain normal even in patients with advanced gastroparesis.
7. The main pathogenetic factors in diabetic gastroparesis are vagal autonomic neuropathy and interstitital cells of Cajal (also known as Farmer’s cells) pathology.
8. Gastric emptying of a solid-phase meal by scintigraphy is considered the gold-standard for the diagnosis of gastroparesis.
9. Gastroparesis is rarely an isolated finding. 17% to 85% have concomitant small bowel dysmotility.
10. Dietary recommendations for patients with gastroparesis should include frequent small meals low in fat and high in complex carbohydrates
11. Byetta, a GLP-1 analog to treat post-prandial hyperglycemia may cause or worsen gastroparesis.
12. Erythromcyin is more effective IV than po.