GASTROENTEROLOGY ARTICLE OF THE WEEK
September 2, 2010
McColl KE. Helicobacter pylori Infection. N Engl J Med 2010;362:1597-1604
1. H. pylori causes an increased susceptibility to duodenal ulcer by which of the following mechanisms
a. Direct invasion of duodenal intestinal epithelium
b. Increased gastrin secretion
c. By invading the fundus of the stomach and stimulating acid secretion
d. By colonizing gastric metaplastic epithelium in the duodenum
True or False
2. The urea breath test has a higher sensitivity for H. pylori infection compared to the stool antigen test
3. H. pylori infection increases the risk of adenocarcinoma of the cardia
4. Approximately 15% to 20% of persons infected with H. pylori develop duodenal or ulcer disease
5. H. pylori infection, in the absence of mucosal ulceration, is a well recognized cause of non-ulcer dyspepsia
6. The sensitivity of the IgG antibody test for H. pylori in detecting infection is 85%
7. A 70 y/o patient with a normal EGD performed for evaluation of occasional nausea was found to have H. pylori. After relapsing following appropriate initial therapy for H. pylori he should be re-treated a second and third time until eradicated