GASTROENTEROLOGY ARTICLE OF THE WEEK
March 16, 2006
Irving PM, Pasi KJ, Rampton DS. Thrombosis and inflammatory bowel disease. Clin Gastroenterol Hepatol 2005;3:617-28.
1. Possible causes of prothrombotic changes in IBD include
a. hyperhomocysteinemia
b. Immobilization and need for surgery
c. acute phase response from inflammation
d. excess B6 levels
True or False
2. IBD patients have a 3-fold increased risk of DVT or pulmonary embolus
3. Inherited prothrombotic abnormalities are more common in patients with IBD
4. Intravascular fibrin deposition may lead to granulomatous destruction of mesenteric blood vessels and cause or perpetuate the changes seen in Crohn’s disease.
5. About 80% of IBD patients with thrombotic complications have evidence of a hypercoagulable state
6. Patients with IBD often show evidence of increased platelet count and increased platelet aggregation
7. Platelet activation and platelet-leukocyte aggregates (PLA’s) are more common when IBD is active
8. Anti-thrombotic therapy is not effective in the treatment of IBD