GASTROENTEROLOGY ARTICLE OF THE WEEK
May 14, 2009
Feagins LA, Kane SV. Sexual and reproductive issues for men with inflammatory bowel disease. Am J Gstroenterol 2009;104:768-773.
1. Which of the following intervention(s) is (are) more likely to cause sexual dysfunction in me
a. Treatment with ASA suppositories
b. Treatment with prednisone
c. Proctoclectomy with ileal pouch anastomosis
d. Treatment of moderate depression associated with UC
e. Treatment with high dose infliximab (10 mg/kg)
True or False
2. Infliximab may affect sperm quality, but effect on conception has not been well studied
3. The oligospermia associated with sulfasalazine therapy can be overcome by minimizing the dose of sulfasalzine
4. The rate of sexual dysfunction in men after total proctocolectomy and IPAA is approximately 25%
5. Pregnancies fathered by men with active IBD tend to have worse outcomes than when both parents are healthy
6. 5-ASA causes oligospermia
7. 6MP and or azathioprine causes no reduction in sperm quality
8. Men should avoid fathering a child while on methorexate therapy and for 4 months after stopping methotrexate
9. Prostate cancer in IBD may be slightly increased, annual rectal exam for patients over 50 that have undergone IPAA is recommended