GASTROENTEROLOGY ARTICLE OF THE WEEK
April 26, 2012
Ochsenkuhn T, D’Haens G. Current misunderstandings in the management of ulcerative colitis. Gut 2011;60:1294-1299.
1. True statements regarding long-term outcomes after colectomy and IPAA include
a. Bowel movement frequency of 5 or more episodes per day occurs in <20%
b. Excellent nighttime continence is reported only by about 40% of patients
c. Pouchitis is the most common complication
d. Almost 50% of females become infertile
True or False
2. Colectomy with IPAA is associated with long-term complications in <5% of patients
3. In general, remission of UC can be assumed if the patient has no symptoms
4. 8-week complete mucosal healing with 4.8 gm of mesalamine therapy rarely exceeds 40%
5. Infliximab induces mucosal remission at 8 weeks in over 60% of patients
6. Infliximab efficacy in UC is comparable to the efficacy seen in Crohn’s
7. Absence of mucosal healing at week 8 predicts a higher risk of colectomy in the future